Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by ROSNER, M. H.
Right arrow Articles by CARTER, D. E.
Right arrow Search for Related Content
PubMed
Right arrow Articles by ROSNER, M. H.
Right arrow Articles by CARTER, D. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1987 Oxford University Press

research-article

Metabolism and Excretion of Gallium Arsenide and Arsenic Oxides by Hamsters following Intratracheal Instillation1

MITCHELL H. ROSNER and DEAN E. CARTER

Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona Tucson, Arizona 85721

The increasing use of gallium arsenide (GaAs) in the electronics industry has produced the need for pharmacokinetic and toxicologic data on GaAs. The disposition in male Syrian golden hamsters (n = 4) following intratracheal instillation of GaAs (mean volume diameter 5.8 µm), arsenic(III) oxide (arsenite), and arsenic(V) oxide (arsenate) at a dose of 5 mg/kg body weight was examined. Blood, kidney, liver, and lung samples were collected at 1, 2, and 4 days after administration. Excreta were collected daily. Urinary metabolite profiles were determined after separation on a mixed anion–cation-exchange column. Total As content was analyzed by direct hydride flame atomic absorption spectrophotometry after digestion. Arsenic blood levels after GaAs, arsenite, and arsenate administration were 0.185 ± 0.041, 0.596 ± 0.117, and 0.3 10 ± 0.045 ppm, respectively, after Day 1. Arsenic blood levels after GaAs administration increased to 0.279 ± 0.021 ppm on Day 2 indicating continued absorption while levels decreased for the arsenite and arsenate groups. At Day 1 the liver contained 0.565 ± 0.036, 2.62 ± 0.26, and 0.579 ± 0.144% of the arsenic dose of GaAs, arsenite, and arsenate, respectively. The" arsenite and arsenate were rapidly excreted in the urine with almost half the dose appearing after 4 days; in contrast, only about 5% of the GaAs was found at the corresponding time. Total recoveries, as arsenic equivalents, for the three compounds were between 75 and 80%. Ratios of the two major urinary metabolites (dimethylarsinic acid/total Inorganic As species) were 1.41, 1.71, and 0.983 for GaAs, arsenite, and arsenate, respectively. GaAs is metabolized to the same compounds as arsenite and arsenate, and shows a metabolic profile most similar to that observed for sodium arsenite.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.