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Toxicological Sciences 55, 17-23 (2000)
Copyright © 2000 by the Society of Toxicology

Forum

Is the Human Carcinogen Arsenic Carcinogenic to Laboratory Animals?

James Huff1, Po Chan and Abraham Nyska

Division of Intramural Research; National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Received August 3, 1999; accepted January 4, 2000

Arsenic has long been known to cause cancer in humans (Hutchinson, 1987Go, 1988Go), and has been correlated convincingly with cancers of the skin, lung, liver, kidney, and urinary bladder (IARC, 1987Go; NTP, 2000Go). Paradoxically, we now know that arsenic has been shown to be "anticarcinogenic" as well, and of potential benefit in the treatment of acute promyelocytic leukemia (Zhu et al., 1999Go). Whereas this is a major cancer chemotherapeutic advance, we believe use of arsenicals in human medicine must be tempered by toxicological realities (Huang et al., 1998Go; Huff et al., 1999Go). Nonetheless, most if not all cancer chemotherapeutic agents are carcinogenic to animals, and cause eventual second primaries in humans.

In summarizing the informative and valued proceedings from a recent symposium on arsenic, Goering et al. (1999) stated that "animal carcinogenicity data for arsenic is considered either negative or . . . [Full Text of this Article]

ACKNOWLEDGMENTS

NOTES

REFERENCES


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