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Toxicological Sciences 55, 233-234 (2000)
Copyright © 2000 by the Society of Toxicology

Profiles in Toxicology

Microsomal Enzyme Induction

Robert Snyder1

Department of Pharmacology and Toxicology, Rutgers University College of Pharmacy, and Environmental and Occupational Health Sciences Institute, Rutgers University, EOHSI-170 Frelinghuysen Road, Piscataway, NJ 08855-1179

Received September 3, 1999; accepted September 7, 1999

Early studies on bacteria demonstrated that many organisms were capable of growth and survival in a variety of different media. In modern terms, these studies showed that genomic function could be altered by environmental factors. It was discovered that various microorganisms were capable of growth at different temperatures, at different pH values, and in different salt solutions. Furthermore, they could often adapt to changes of nutrients in their media. For example, bacteria were found to synthesize the amino acid, arginine, when arginine was not present in the culture medium. When present, arginine acted as a repressive factor toward synthesis of the enzymes . . . [Full Text of this Article]

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