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Toxicological Sciences 60, 194-195 (2001)
Copyright © 2001 by the Society of Toxicology

PROFILES IN TOXICOLOGY

Paré's Law: The Second Law of Toxicology

B. D. Goldstein1, and M. A. Gallo

Environmental and Occupational Health Sciences Institute (EOHSI), 170 Frelinghuysen Road, Piscataway, New Jersey 08854

There are three so-called laws that underlie the science of toxicology. Paracelsus is usually considered to be the father of toxicology, having formulated the first law, which states that the dose makes the poison. The second law concerns the specificity of toxic effects of individual chemicals, a specificity due to the unique chemical structure of the agent and the laws of biology that govern the response. The third law is that humans are animals and that therefore the study of animals can provide useful insight into effects in humans.

We can find no record of any eponym being used to designate the second law of toxicology. We propose that the place of honor for having clearly enunciated this second law, which encompasses recording an unfortunate experiment to prove his dictum, belongs to Paré, who stated that "Poyson ...kils by a certaine specifick antipathy contrary to our nature" . . . [Full Text of this Article]

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