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Toxicological Sciences 64, 4-6 (2001)
Copyright © 2001 by the Society of Toxicology

PROFILES IN TOXICOLOGY

A Short History of Lung Cancer

Hanspeter Witschi

ITEH and Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616

For correspondence via fax: (530) 752-5300. E-mail: hrwitschi@ucdavis.edu.

"Lung cancer continues to be the leading cause of death in both men and women in the US, with over 158,900 deaths in 1999. Worldwide, lung cancer kills over 1 million people a year. Extensive prospective epidemiologic data clearly establish cigarette smoking as the major cause of lung cancer. It is estimated that about 90% of male lung cancer deaths and 75–80% of lung cancer deaths in the US are caused by smoking each year" (Hecht, 1999). Clearly, lung cancer is an important and widespread disease that constitutes a major public health problem. This was not always so. Some 150 years ago, it was an extremely rare disease. In 1878, malignant lung tumors represented only 1% of all cancers seen at autopsy in the Institute of Pathology of the University of Dresden in Germany. By 1918, the percentage had risen to almost 10% and by 1927 to more than 14%. . . . [Full Text of this Article]

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