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Toxicological Sciences 66, 4-6 (2002)
Copyright © 2002 by the Society of Toxicology

PROFILES IN TOXICOLOGY

The Missing Link: The Story of Karl Paul Link

Jerold A. Last,1

Toxic Substances Program, University of California, Davis, California 95616-8723

If you ever wondered why the well-known rat poison is called Warfarin, it is from the initials WARF for Wisconsin Alumni Research Foundation. WARF funded the initial studies on coumarins in Karl Paul Link's laboratory, which gave rise to this compound and to its close relative, dicoumarol. Professor Link was a pioneer in what would now be called basic research in toxicology. Perhaps because his research was so oriented to biochemistry and so interdisciplinary, his name seems to be lost when pioneers in toxicology are discussed. His seminal work began with a problem among dairy cattle, the major industry in Wisconsin, which needed a solution.

Sweet clover (Melilotus alba and M. officinalis) is grown as a green manure and hay crop in the northern U.S. and in Canada. Its coumarin content gives it a distinctive sweet odor similar to vanilla. Its use as hay was widespread in the . . . [Full Text of this Article]

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Home page
 J. Biol. Chem.Home page
N. Kresge, R. D. Simoni, and R. L. Hill
Hemorrhagic Sweet Clover Disease, Dicumarol, and Warfarin: the Work of Karl Paul Link
J. Biol. Chem., February 25, 2005; 280(8): e5 - e5.
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