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Toxicological Sciences 66, 173-175 (2002)
Copyright © 2002 by the Society of Toxicology

PROFILES IN TOXICOLOGY

The International Symposium on Biological Reactive Intermediates

Robert Snyder,1

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Road, Piscataway, New Jersey 08854

In his pioneering work entitled Detoxication Mechanisms: The Metabolism of Drugs and Allied Organic Compounds (John Wiley and Sons, New York, 1947), R. Tecwyn Williams wrote: "Although the term `detoxication' or `detoxication mechanism' implies some process or processes whereby toxicity in a compound is reduced or abolished, in its modern usage it includes not only changes involving a reduction in toxicity but also those involving an increase in toxicity." A number of mechanisms have been described by which the toxicity of a chemical is enhanced by metabolism, including the production of chemically reactive species called "biological reactive intermediates" or BRI. Following early reports by Miller and Miller (1966) relating the macromolecular covalent binding of carcinogen metabolites to carcinogenesis, a series of papers appeared in the Journal of Pharmacology and Experimental Therapeutics from the laboratory of B. . . . [Full Text of this Article]

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REFERENCES


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