ToxSci Advance Access originally published online on March 10, 2004
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Toxicological Sciences 78, 175-177 (2004)
Toxicological Sciences vol. 78 no. 2 © Society of Toxicology; all rights reserved.
EDITORIAL |
On the Application of Data on Mode of Action to Carcinogenic Risk Assessment
Department of Oncology, Box 571465, Georgetown University, Lombardi Cancer Center Room S150, 3800 Reservoir Road NW, Washington, District of Columbia 20057-1465
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In the Forum article in this issue of Toxicological Sciences, Cohen et al. (2004)
discuss a framework for systematic analysis of data on modes of carcinogenic action of chemicals in experimental animals, and its application to cancer risk assessment. This summarizes an exercise recently completed by the ILSI Risk Science Institute (Cohen et al., 2003
), which builds on a harmonization initiative of the International Programme on Chemical Safety (Sonich-Mullin et al., 2001
). The framework approach is based fundamentally on advances that have been achieved in recent decades in understanding the pathogenesis of neoplasia. It is now recognized that
1 For correspondence via fax: (202) 784-3034. E-mail: jr332@georgetown.edu