Skip Navigation


ToxSci Advance Access originally published online on June 16, 2004
Toxicological Sciences 2004 81(1):1-2; doi:10.1093/toxsci/kfh196
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
81/1/1    most recent
kfh196v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (6)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Boekelheide, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Boekelheide, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Toxicological Sciences vol. 81 no. 1 © Society of Toxicology 2004; all rights reserved.

TOXICOLOGICAL HIGHLIGHT

Cracking the Nut

Kim Boekelheide1

Received June 10, 2004; accepted June 10, 2004

The first 10% of the full text of this article appears below.

Phthalate esters impart flexibility to hard plastics, are used as inert ingredients in cosmetics and personal hygiene products, and are ubiquitous environmental contaminants. Finding the underlying molecular mechanism of phthalate-induced testicular injury has been a vision quest of male reproductive toxicologists for many decades. Since 1945, when Shaffer et al. (1945)Go first described "tubular atrophy and degeneration ... resembling senile changes" (p. 131) in the testis following exposure to di-(2-ethylhexyl) phthalate, phthalates have become the most studied and most thoroughly characterized class of testicular toxicants. What is especially exciting about the phthalates for mechanistic toxicologists is the rapid onset of testis-specific abnormalities; "rapid" and "specific" should mean simple and straightforward, right? Wrong!

A number of mechanistic hypothesis . . . [Full Text of this Article]

1 For correspondence via fax: (401) 863-9008. E-mail: Kim_Boekelheide@brown.edu.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
K. J Johnson, J. B Hensley, M. D Kelso, D. G Wallace, and K. W Gaido
Mapping Gene Expression Changes in the Fetal Rat Testis Following Acute Dibutyl Phthalate Exposure Defines a Complex Temporal Cascade of Responding Cell Types
Biol Reprod, December 1, 2007; 77(6): 978 - 989.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol SciHome page
S. A. Lahousse, D. G. Wallace, D. Liu, K. W. Gaido, and K. J. Johnson
Testicular Gene Expression Profiling following Prepubertal Rat Mono-(2-ethylhexyl) Phthalate Exposure Suggests a Common Initial Genetic Response at Fetal and Prepubertal Ages
Toxicol. Sci., October 1, 2006; 93(2): 369 - 381.
[Abstract] [Full Text] [PDF]