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Toxicological Sciences 2005 84(2):212-213; doi:10.1093/toxsci/kfi111
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Toxicological Sciences vol. 84 no. 2 © The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

TOXICOLOGICAL HIGHLIGHT

Focal Adhesion Kinase as a Potential Target in Arsenic Toxicity

Jie Liu1 and Michael P. Waalkes

Laboratory of Comparative Carcinogenesis, National Cancer Institute at NIEHS, 111 Alexander Drive, Research Triangle Park, North Carolina, 27709

1 To whom correspondence should be addressed. Fax: (919) 541-3970. E-mail: Liu6@niehs.nih.gov.

Received January 28, 2005; accepted February 3, 2005

The first 10% of the full text of this article appears below.

Arsenic is one of the highest priority hazardous substances around the world, and is well known for its toxicity and carcinogenicity in humans (National Research Council, 1999Go). Arsenic trioxide also finds use as a remarkably effective chemotherapeutic agent in the treatment of acute promyelocytic leukaemia (APL), and may find use in the treatment of certain solid tumors (Chen et al., 2002Go). This paradoxical nature of arsenic as a carcinogenic anti-cancer agent is dependent on the dose and duration of exposure, the status of various diseases, and the complex cellular interactions of this remarkable metalloid (National Research Council, 1999Go; Qian et al., 2003Go). In this issue of Toxicological Sciences, Yancy et al. (pp. 1–9) reported the effects of sodium . . . [Full Text of this Article]


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