© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
TOXICOLOGICAL HIGHLIGHT |
Highlight for Phenols, Quinolines, Indoles, Benzene and 2-Cyclopenten-1-ones Are Oviduct Toxicants in Cigarette Smoke, by Prue Talbot, Karen Riveles, and Ryan Rosa: List of Tobacco-Smoke Constituents That Are Harmful for Reproduction Grows—Passive Smokers May Be at Risk
University of California San Francisco, Department of Cell and Tissue Biology, San Francisco, California 94143
1 To whom correspondence should be addressed. E-mail: genbacev@comcast.net.
Received May 1, 2005; accepted May 9, 2005
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Epidemiological studies provide compelling evidence that smoking has serious negative consequences on fertility and pregnancy outcome. Numerous epidemiological studies have linked smoking with higher frequency of ectopic pregnancies and problems related to the oviduct function (Castles et al., 1999
). Smoking decreases the success rate of in vitro fertilization and, more specifically, reduces the rates of oocyte production (reviewed by Shiverick and Salafia, 1999). Clearly, we do not understand the exact mechanisms by which smoking decreases fertility and negatively affects pregnancy outcome. One of the reasons is the complex composition of the cigarette smoke,