© The Author 2005. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
TOXICOLOGICAL HIGHLIGHT |
Variation in Gut Microbiota Strongly Influences Individual Rodent Phenotypes
Biological Chemistry, Biomedical Sciences Division, Faculty of Medicine, Imperial College, London, SW7 2AZ, UK
1 To whom correspondence should be addressed. E-mail: elaine.holmes@imperial.ac.uk.
Received July 4, 2005; accepted July 13, 2005
Key Words: gut microbiota rodent phenotypes; metabolic profiling.
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Understanding genetic and phenotypic differences between experimental animals (both within a single population and between populations held at different sites) is potentially important in explaining variability in responses to drugs and other stressors. Population changes in endogenous and exogenous metabolism in laboratory animal colonies have often been ascribed to genetic drift in the experimental animals themselves. This undoubtedly occurs in laboratory rodents; however, phenotypic drift in animal colonies can have an immediate and potentially greater short term impact on normal physiological variation and mammalian metabolism, as exemplified by Robosky et al. in this issue of Toxicological Sciences. They describe clear and stable metabolic differentiation of
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