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TOXICOLOGICAL HIGHLIGHT |
The Implications of Low-Affinity AhR for TCDD Insensitivity in Frogs
United States Geological Survey, Department of Biological Sciences, University of Maine, Orono, Maine 04469
Received September 7, 2005; accepted September 8, 2005
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The article by Lavine et al. (2005) in this issue provides a molecular explanation for the long-recognized but not understood dioxin-insensitivity of the amphibian-based toxicant screen FETAX (Frog Embryo Teratogenesis Assay—Xenopus). FETAX is the industry standard for identifying potential human developmental toxicants and teratogens (NIEHS, 2000
), and it is widely used as a screening tool for evaluating amphibian sensitivity to environmental contaminants (Mann and Bidwell, 2000). By providing insights into the molecular mechanisms underlying frog response to environmental contaminants, the work of Lavine et al. (2005) will enable ecotoxicologists to refine, improve, and advance the use of frogs for toxicant screening methods for human developmental/teratogenic agents and the use of FETAX for ecotoxicological applications, an area of particular importance given the continuing rise in global occurrences of amphibian deformities.
The crux of the findings reported by Lavine et al. (2005) is that TCDD,
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