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Extending the Good Diet, Good Health Paradigm: Modulation of Breast Cancer Resistance Protein (BCRP) by Flavonoids
Department of Metabolism and Pharmacokinetics, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Pharmaceutical Research Institute, Pennington, NJ 08534
1 For correspondence via fax: (609) 818-7130. E-mail: mengmeng.wang@bms.com.
Received February 1, 2007; accepted February 1, 2007
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Flavonoids, important constituents of the human diet, are found in a variety of fruits, vegetables, and beverages including wine and teas. As a class, flavonoids are recognized to have numerous biological activities, and a healthy diet rich in fruit and vegetables is linked directly to a reduced risk of cancer (Lee et al., 1991
; Middleton et al., 2000) or coronary heart disease (Hertog et al., 1993; Kelly, 2001). With increasing recognition of the potential long-term benefits of these components, they are also being used more frequently as dietary supplements. The biological effects ascribed to the anticancer actions of flavonoids are diverse and include their ability to modulate (1) signal transduction pathways involved in cell proliferation and angiogenesis, (2)