Skip Navigation

This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Brown, K. M.
Right arrow Articles by Papaconstantinou, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, K. M.
Right arrow Articles by Papaconstantinou, A. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Toxicological Sciences 56, 252 (2000)
Copyright © 2000 by the Society of Toxicology

Toxicological Highlight

Response

Ken M. Brown and Andriana D. Papaconstantinou

Department of Biological Sciences George Washington University Washington, DC 20052

In our study, we showed that the increase in uterine weight and uterine epithelial cell height induced by subcutaneous administration of bisphenol A (BPA) to ovariectomized B6C3F1 mice was reversed by co-administration of the estrogen receptor antagonist, ICI 182,780 (ICI). The maximum response to BPA was less than that for estradiol (E2), and more ICI was needed to block these responses to BPA than to E2. Little is known about the potential differences in BPA and E2 binding sites on the estrogen receptor, intrinsic activity, or their interaction with the ICI binding site(s) that may account for the observed differences in the pharmacology of E2- and BPA-mediated responses. Nevertheless, our data suggest that the BPA-induced increase in uterine weight and uterine epithelial cell height are mediated by the estrogen receptor. Our study does not rule out additional mechanisms of BPA-mediated uterotrophic effects, especially on the stromal and myometrial layers of the uterus, and these are briefly examined in the Discussion section of our paper.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?



This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Brown, K. M.
Right arrow Articles by Papaconstantinou, A. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, K. M.
Right arrow Articles by Papaconstantinou, A. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?