TABLE 4 Organ Weights of PND 90 Male Rats Exposed in Utero to Finasteride during GD 12–21
|
Finasteride (mg/kg/day)
|
| Parameters |
0 |
0.01 |
0.1 |
1.0 |
10 |
100 |
|
| No. of litters |
5 |
5 |
4 |
5 |
5 |
6 |
| No. of animals |
33 |
30 |
23 |
30 |
31 |
33 |
| Terminal body weight (g)a |
508 ± 15 |
504 ± 15 |
514 ± 17 |
505 ± 16 |
497 ± 15 |
481 ± 14 |
| Liver (g)b |
20.1 ± 0.1 |
19.5 ± 0.3 |
19.6 ± 0.4 |
19.8 ± 0.3 |
20.1 ± 0.3 |
19.6 ± 0.3 |
| Kidneys (g)b,c |
3.37 ± 0.07 |
3.36 ± 0.08 |
3.59 ± 0.07 |
3.48 ± 0.07 |
3.41 ± 0.07 |
3.41 ± 0.07 |
| Adrenal glands (mg)b,c |
40.4 ± 2.1 |
36.5 ± 2.2 |
44.1 ± 2.6 |
41.1 ± 2.2 |
37.5 ± 2.2 |
37.1 ± 2.1 |
| Right testis (descended ) (g)b |
1.59 ± 0.04 |
1.71 ± 0.04 |
1.75 ± 0.05 |
1.75 ± 0.05 |
1.73 ± 0.05 |
1.68 ± 0.06 |
| Right testis (ectopic) (g)b |
No tissued |
No tissued |
No tissued |
No tissued |
1.09 ± 0.20 |
1.01 ± 0.11 |
| Left testis (descended) (g)b |
1.72 ± 0.05 |
1.72 ± 0.06 |
1.76 ± 0.06 |
1.76 ± 0.06 |
1.66 ± 0.06 |
1.69 ± 0.07 |
| Left testis (ectopic) (g)b |
No tissued |
No tissued |
No tissued |
0.53 ± 0.39 |
1.12 ± 0.18 |
0.91 ± 0.11 |
| Right epididymis (descended) (g)b |
0.56 ± 0.01 |
0.56 ± 0.01 |
0.57 ± 0.01 |
0.56 ± 0.01 |
0.55 ± 0.01 |
0.53 ± 0.01 |
| Right epididymis (ectopic) (g)b |
No tissued |
No tissued |
No tissued |
No tissued |
0.36 ± 0.05 |
0.34 ± 0.03 |
| Left epididymis (descended) (g)b |
0.52 ± 0.01 |
0.51 ± 0.01 |
0.53 ± 0.01 |
0.51 ± 0.01 |
0.50 ± 0.01 |
0.49 ± 0.02 |
| Left epididymis (ectopic) (g)b |
No tissued |
No tissued |
No tissued |
0.19 ± 0.10 |
0.33 ± 0.05 |
0.27 ± 0.03 |
| Dorsolateral prostate (mg)b,e |
602 ± 28 |
618 ± 29 |
532 ± 33 |
571 ± 29 |
486 ± 29* |
402 ± 48* |
| Ventral prostate (mg)b,e |
542 ± 42 |
500 ± 42 |
477 ± 48 |
490 ± 43 |
417 ± 42* |
303 ± 42* |
| Seminal vesicles & coagulating gland (w/fluid) (g)b,e |
1.51 ± 0.08 |
1.42 ± 0.08 |
1.30 ± 0.09 |
1.54 ± 0.08 |
1.35 ± 0.08 |
1.15 ± 0.09* |
| Levator ani bulbocavernosous (g)b |
1.09 ± 0.04 |
1.16 ± 0.04 |
0.97 ± 0.05 |
0.89 ± 0.04* |
0.74 ± 0.04* |
0.58 ± 0.04* |
| Bulbourethral glands (mg)b,c |
12.9 ± 0.8 |
12.3 ± 0.8 |
11.8 ± 0.9 |
13.8 ± 0.8 |
11.9 ± 0.9 |
6.6 ± 1.0* |
|
| aNested litter means ± SE. |
| bNested litter means ± SE with body weight as covariate. Malformed tissues are not included. |
| cPaired weights. |
| dUndescended tissues were not observed in this dose group. |
| eThe 100 mg/kg/day dose group does not include organ weights that were too small to be dissected or were absent. |
| *p < 0.05 compared with the control group. |
|
