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FIG. 6. Schematic representation of the integrated addition and interaction model. Rmixture represents the response to the mixture. Similar-acting chemicals are placed in a cassette. Toxicity associated with the cassette is calculated using the concentration addition model. Toxicokinetic interactions between chemicals are incorporated as modifiers of concentrations of chemicals within the cassettes. Total mixture toxicity associated with all cassettes is calculated using the response addition model.
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