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© 1981 Oxford University Press

other

Renal Reabsorption and Secretion of {delta}-aminolevulinic Acid in the RatA

E.J. O'FLAHERTY, P.B. HAMMOND and E. TAYLOR

Department of Environmental Health, University of Cincinnati Cincinnati, Ohio 45267

Renal Reabsorption and Secretion of {delta}-aminolevulinic Acid in the Rat. O'Flaherty, E.J., Hammond, P.B. and Taylor, E. (1981). Fundam. Appl. ToxicoL 1:278–281. Renal mechanisms for handling {delta}-aminolevulinic acid (ALA) were investigated in control and lead-exposed rats infused with ALA at a range of rates which produced plasma ALA as high as 2380 ng/mL. The presence of both reabsorption and secretion mechanisms was demonstrated. Reabsorption is the more efficient of the two mechanisms at low plasma ALA concentrations, and masks secretion in this range. Net secretion is observed at very high plasma ALA concentrations. Exposure to up to 2000 µg lead/mL of drinking water for 12 to 18 months had no measurable effect on net ALA excretion at a given plasma ALA level.


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