Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by McFADDEN, D. P.
Right arrow Articles by MAICKEL, R. P.
Right arrow Search for Related Content
PubMed
Right arrow Articles by McFADDEN, D. P.
Right arrow Articles by MAICKEL, R. P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1981 Oxford University Press

research-article

The Role of Methemoglobin in Acute Butyl Nitrite Toxicity in Mice

DAVID P. McFADDEN, GARY P. CARLSON and ROGER P. MAICKEL

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University West Lafayette, Indiana 47907

The Role of Methemoglobin in Acute Butyl Nitrite Toxicity in Mice. McFadden, David P., Carlson, Gary P. and Maickel, Roger P. (1981). Fundam. Appl. Toxicol. 1:448–451. When mice were exposed to butyl nitrites in an inhalation chamber, a significant level of methemoglobinemia is produced. The potency order for methemoglobin production of the four butyl nitrites (n-, iso-, sec-, tert-) is the same as that of their lethal concentrations (LCSO values) and parallels the ability of the agents to cause methemoglobin formation in mouse erythrocytes in vitro. Pretreatment with a single dose of methylene blue prevents the methemoglobin formation and protects against the lethality of the butyl nitrites.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.