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© 1988 Oxford University Press

research-article

Uptake of 19 Hydrocarbon Vapors Inhaled by F344 Rats

A. R. DAHL, E. G. DAMON, J. L. MAUDERLY, S. J. ROTHENBERG, F. A. SEILER and R. O. MCCLELLAN

Lovelace Biological and Environmental Research Institute, Inhalation Toxicology Research Institute P.O. Box 5890, Albuquerque, New Mexico 87185

Received March 26, 1987; accepted October 6, 1987

The Uptake of 19 Hydrocarbon Vapors Inhaled by F344 Rats. DAHL, A. R., DAMON, E. G., MAUDERLY, J. L., ROTHENBERG, S. J., SEILER, F. A., AND MCCLELLAN, R. O. (1988). Fundam Appl. Toxicol. 10, 262–269. The comparative rates of uptake of 19 hydrocarbon vapors by rats were determined by a dual-column gas chromatograph method. The hydrocarbons ranged in volatility from propylene (BP –47.7°C) to 1,2,4-trimethylbenzene (BP 169°C). Representative compounds from the chemical classes of alkenes, alkynes, straight-chain and branched alkanes, alicyclics, and aromatics were examined. Trends observed included: (1) highly volatile hydrocarbons were less well-absorbed than less volatile hydrocarbons; (2) unsaturated compounds were better absorbed than saturated ones; and (3) branched hydrocarbons were less well-absorbed than unbranched ones. The data indicate that uptake rates among inhaled hydrocarbon vapors may be predicted from the molecular structures and physical properties of the hydrocarbons.


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