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ToxSci Advance Access originally published online on May 8, 2007
Toxicological Sciences 2007 100(1):29-35; doi:10.1093/toxsci/kfm113
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Published by Oxford University Press 2007.

Inclusion of Biomarkers for Detecting Perturbations in the Heart and Lung and Lipid/Carbohydrate Metabolism in National Toxicology Program Studies

June K. Dunnick1, Kristina A. Thayer and Gregory S. Travlos

National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

1 To whom correspondence should be addressed. Fax: (919) 541-4255. E-mail: dunnickj{at}niehs.nih.gov.

Received March 16, 2007; accepted May 3, 2007


  Abstract

Environmental factors and exposures may contribute to many serious diseases afflicting humans. Biomarkers are useful to understand disease processes and identify early events leading to disease. The National Toxicology Program (NTP) convened a workshop in September 2006 to help identify biomarkers that could be used in toxicology studies with rodents to predict disease outcome and detect early events in disease processes. Expert scientists reviewed biomarkers for disease/injury related to the heart, lung, and/or changes in lipid/carbohydrate metabolism and made recommendations for those that could be incorporated into NTP studies on a routine or selective basis. Although numerous biomarkers were discussed, only a few were considered amenable for routine use. This article summarizes recommendations for the most promising biomarkers and presents the NTP perspective on those that will be included in the bioassay program on a routine or special study basis. Breakout group reports and additional information on the workshop, including participants, presentations, and background materials, are posted on the NTP Web site http://ntp.niehs.nih.gov/go/20940.

Key Words: biomarkers; cardiovascular system; lipids.


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