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ToxSci Advance Access originally published online on September 25, 2007
Toxicological Sciences 2008 101(1):179-180; doi:10.1093/toxsci/kfm249
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© The Author 2007. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

To the Editor

Dominique Lison and Julie Muller

Université catholique de Louvain, Industrial Toxicology and Occupational Medicine, 1200 Brussels, Belgium

Received August 20, 2007; accepted August 20, 2007

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In their recent publication in Toxicological Sciences Mitchell et al. (2007) report on the lung and systemic responses to carbon nanotubes (CNT) in mice. After 14 days of inhalation exposure to a maximum of 5 mg CNT/m3, no significant lung toxicity was reported but immunological changes were noted in the spleen. These results contrast with the marked inflammatory and fibrotic lung responses reported by other investigators who used single wall CNT intratracheal (i.t.) injection in mice (Lam et al., 2004Go) or rats (Warheit et al.. . . [Full Text of this Article]


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