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Toxicological Sciences 2008 103(2):409-410; doi:10.1093/toxsci/kfn036
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Use of the Pup as the Statistical Unit in Developmental Neurotoxicity Studies: Overlooked Model or Poor Research Design?

Marcia Hardy and Todd Stedeford

Albemarle Corporation, Health, Safety and Environment, Baton Rouge, Louisiana

Received December 7, 2007; accepted February 7, 2008

The first 10% of the full text of this article appears below.

Fischer et al. (2008)Go report that BDE-99 (2,2'4,4',5-pentabromodiphenyl ether) and methylmercury exposure to mouse pups on postnatal day 10 disrupted spontaneous behavior, reduced habitation, and impaired learning/memory abilities. The authors employed an experimental design developed in their laboratory stating:

"[i]n this neonatal animal model each of the different treatment groups comprise mice from three to four different litters. Randomly selecting animals from at least three different litters will . . . [Full Text of this Article]


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