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ToxSci Advance Access originally published online on April 2, 2008
Toxicological Sciences 2008 104(1):228-230; doi:10.1093/toxsci/kfn067
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Comments on "Evaluation of Estrogenic Activities of Aquatic Herbicides and Surfactants Using a Rainbow Trout Vitellogenin Assay"

Vincent Kramer, Craig Blewett and Michael Gersich

Dow AgroSciences LLC, Indianapolis, IN 46268, T: 317-337-3137, E-mail: vjkramer@dow.com

Received February 6, 2008; accepted March 2, 2008

The first 150 words of the full text of this article appear below.

In reading the paper, "Evaluation of estrogenic activities of aquatic herbicides and surfactants using a rainbow trout vitellogenin assay" (Xie et al., 2005Go, Toxicol. Sci. 87, 391–398), we have identified a number of issues that require additional detail or possible correction of the information and conclusions as presented.

A major technical issue concerns the use of "juvenile" trout combined with very limited replication, which calls into question the validity of the conclusions derived from the experimental results. The authors apparently did not account for an underlying and uncontrollable source of variability that confounds interpretation of these results. The sex of each individual trout used in the studies was not identified. Instead, the trout are described only as: "Juvenile rainbow trout (standard length: 11.5 ± 2.2 cm)." The Toxicological Sciences article also references their work on 17β-estradiol in Xie et al. (2004)Go, which describes the trout used . . . [Full Text of this Article]


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