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ToxSci Advance Access originally published online on April 2, 2008
Toxicological Sciences 2008 104(1):231-233; doi:10.1093/toxsci/kfn068
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Response to: Comments on "Evaluation of Estrogenic Activities of Aquatic Herbicides and Surfactants Using a Rainbow Trout Vitellogenin Assay"

Daniel Schlenk

Department of Environmental Science, University of California, Riverside, California 92521

Received March 15, 2008; accepted March 25, 2008

The first 10% of the full text of this article appears below.

We have read the comments of Kramer et al. (unpublished data) on our paper, "Evaluation of estrogenic activities of aquatic herbicides and surfactants using a rainbow trout vitellogenin assay" (Xie et al., 2005aGo).

We appreciate their comments and would like to respond to them.

"JUVENILE" TROUT MAY BE FEMALE

Kramer et al. (unpublished data) suggest that the fish utilized for the analyses were of "mixed sex" and likely confound the estrogenic assay because one or more of the animals utilized for evaluations of feminization could be "female." They indicated that Bon et al. (1997)Go showed that juvenile females possessed 423 µg/ml of vitellogenin whereas males had only 0.38 µg/ml. We wholeheartedly agree with Kramer et al. (unpublished data) that juvenile "females" do possess vitellogenin that is significantly higher than that of males. There are two key terms here that require definition: the first is "juvenile" . . . [Full Text of this Article]

NORMALIZATION TO PLASMA PROTEIN

ESTRADIOL EQUIVALENTS CALCULATIONS

GREATER THAN ADDITIVE RESPONSES

ESTROGENICITY OF 2,4-DICHLOROPHENOXYACETIC ACID

APMP2 VERSUS XIE ET AL. (2005a)


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