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ToxSci Advance Access originally published online on August 6, 2008
Toxicological Sciences 2008 105(2):233-234; doi:10.1093/toxsci/kfn138
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Gene Expression, Dose-Response, and Phenotypic Anchoring: Applications for Toxicogenomics in Risk Assessment

George P. Daston1

Central Product Safety, Procter & Gamble, Cincinnati, Ohio 45253

1 To whom correspondence should be addressed at Central Product Safety, Procter & Gamble, Cincinnati, OH 45253. E-mail: daston.gp@pg.com. Fax: 1-513-627-0323.

Received July 3, 2008; revision received July 3, 2008; accepted July 5, 2008

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There are a number of ways in which global analysis of gene expression may be useful in improving the way we assess the risk of chemical agents, especially at the concentrations to which people are likely to be exposed. The methodology for assessing changes in gene expression is quite sensitive: most of the methods in use today have attomolar or even subattomolar sensitivity. That sensitivity, coupled with the observation that virtually all toxic responses are accompanied by changes in gene expression, suggests that it is possible to use gene expression analysis to determine whether responses at the molecular level continue to occur at dose levels below those that produce frankly adverse effects. This kind of information will be extremely important in addressing controversies about the likelihood of occurrence . . . [Full Text of this Article]


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