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ToxSci Advance Access originally published online on July 3, 2008
Toxicological Sciences 2008 105(2):429-432; doi:10.1093/toxsci/kfn133
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Comments on Respiratory Toxicity of Diacetyl [Re: Morgan, D. L., Flake, G. P., Kirby, P. J., and Palmer, S. M. (2008). Respiratory toxicity of diacetyl in C57Bl/6 mice. Toxicol. Sci. 103, 169–180.]

Brent L. Finley*, David A. Galbraith*,{dagger},1 and David Weill{ddagger}

* ChemRisk, Inc., San Francisco, California 94105 {dagger} Palo Alto Medical Foundation, Palo Alto, California 94301 {ddagger} Stanford University Medical Center, Division of Pulmonary and Critical Care Medicine, Stanford, California 94305-5236

1 To whom correspondence should be addressed at ChemRisk, Inc., 25 Jessie Street at Ecker Square, Suite 1800, San Francisco, CA 94105. Fax: (415) 896-2471. E-mail: dgalbraith@chemrisk.com.

Received May 12, 2008; accepted June 2, 2008

The first 150 words of the full text of this article appear below.

Dear Sirs

Morgan et al. (2008)Go evaluated respiratory responses in mice exposed to heated diacetyl vapors. This research is otentially relevant to the ongoing investigations into food-related industries where it has been suggested that artificial butter flavoring (ABF) and, specifically, diacetyl exposures are associated with serious respiratory effects in workers, including constrictive bronchiolitis, a form of obliterative bronchiolitis (OB).

For the sake of background, constrictive bronchiolitis is a peribronchiolar process of fibrosis, that "surrounds rather than fills the lumen," resulting in "extrinsic compression and obliteration of the airway" (Ryu et al., 2003Go). The deposition of collagen and progressive fibrosis produces an "obliterated" appearance to biopsy specimens, reflecting irreversible distal airway damage with permanent loss of pulmonary function. One must be careful, however, in interpreting the results of tissue analysis. Although histologic signs of inflammation can be suggestive that constrictive bronchiolitis could eventually occur in an individual case, its . . . [Full Text of this Article]


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