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ToxSci Advance Access originally published online on July 3, 2008
Toxicological Sciences 2008 105(2):433-434; doi:10.1093/toxsci/kfn134
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Published by Oxford University Press 2008.

Response to: Comments on Respiratory Toxicity of Diacetyl in C57Bl/6 Mice

Daniel L. Morgan*,1, Gordon P. Flake{dagger}, Patrick J. Kirby* and Scott M. Palmer{ddagger}

* Respiratory Toxicology, Laboratory of Molecular Toxicology, National Toxicology Program/National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 {dagger} Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709 {ddagger} Division of Pulmonary and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710

1 To whom correspondence should be addressed at Respiratory Toxicology, Laboratory of Molecular Toxicology, MD IF-00, NIEHS, Research Triangle Park, NC 27709. Fax: (919) 541-0356. E-mail: morgan3@niehs.nih.gov.

Received June 25, 2008; accepted June 27, 2008

The first 10% of the full text of this article appears below.

We appreciate the opportunity provided by Finley et al. to highlight the rationale for the diacetyl exposure regimens used in our animal studies and their relevance to the actual worker exposure concentrations measured in the sentinel microwave popcorn packaging plant. In addition, we appreciate the opportunity to emphasize the unique respiratory toxicological profile of diacetyl in mice which includes epithelial injury and lymphocytic bronchiolitis after inhalation and fibrohistiocytic lesions in the terminal bronchioles after aspiration.

Worker exposures to diacetyl in the microwave popcorn packaging plants vary considerably, and as with any occupational exposure, it is not possible to duplicate exactly an exposure scenario for all workers. After evaluating the types of worker exposures reported by Kreiss et al. (2002)Go, we designed . . . [Full Text of this Article]


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