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ToxSci Advance Access originally published online on August 28, 2008
Toxicological Sciences 2008 106(2):570-571; doi:10.1093/toxsci/kfn185
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Published by Oxford University Press 2008.

Long-term Cancer Bioassays of Ascorbic Acid

James Huff1

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

1 For correspondence via E-mail: huff1@niehs.nih.gov.

Received July 16, 2008; accepted August 1, 2008

The first 10% of the full text of this article appears below.

Kuroiwa et al. (2008)Go report on the lack of carcinogenesis of coadministration of ascorbic acid and sodium nitrite in male F344 rats, despite causing oxidative DNA damage–associated mutagenicity in vitro and increased levels of 8-hydroxydeoxyguanosine in rat forestomach epithelium. Earlier studies showed that forestomach carcinogenesis was enhanced by this combination after initiation with N-methyl-N'-nitro-N-nitrosoguanidine (Okazaki et al., 2006Go), and forestomach papillomas were induced without prior initiation, using sodium nitrite and sodium ascorbate (Yoshida et al., 1994Go. . . [Full Text of this Article]


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