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ToxSci Advance Access originally published online on August 28, 2008
Toxicological Sciences 2008 106(2):572-574; doi:10.1093/toxsci/kfn181
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© The Author 2008. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org

Nonanimal Alternatives for Skin Sensitization: Letter to the Editor

David W. Roberts*,1 and Grace Y. Patlewicz{dagger}

* School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool L3 3AF, UK {dagger} DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19711

1 To whom correspondence should be addressed at School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK. E-mail: d.w.roberts@ljmu.ac.uk.

Received August 7, 2008; accepted August 10, 2008

The first 150 words of the full text of this article appear below.

Dear Editor,

In a recent issue of Toxicological Sciences, an in vitro test was reported, utilizing genomic markers as predictors of sensitizers (Natsch and Emter, 2008Go). In effect, this is a cell-based protein-binding assay, the gene expression effect measured being the consequence of reaction of the test compound with thiol groups of a cytosolic protein. Compared with current in chemico peptide reactivity assays, it may arguably have the advantage of capturing the more complex reactivity of those compounds which require metabolic activation, the cell's metabolic repertoire being available to such chemicals. Basketter (2008)Go provided a commentary on the performance of this test and, in addition, advocated an integrated holistic framework based on combining data from various sources to formulate insight of the likely sensitizing potency of a chemical. This approach is based on an outline strategy recently proposed by Jowsey et al. (2006)Go which described how data could . . . [Full Text of this Article]


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