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ToxSci Advance Access originally published online on January 23, 2009
Toxicological Sciences 2009 108(1):19-21; doi:10.1093/toxsci/kfp008
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Published by Oxford University Press 2009.
The online version of this article has been published under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that: the original authorship is properly and fully attributed; the Journal and Oxford University Press are attributed as the original place of publication with the correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org

Pragmatic Challenges for the Vision of Toxicity Testing in the 21st Century in a Regulatory Context: Another Ames Test? ...or a New Edition of "the Red Book"?

Bette Meek and John Doull1

McLaughlin Institute for Population Health Risk Assessment, University of Ottawa, Tunney's Pasture, Address Locator 0801C2, Ottawa K1A 0L2, Ontario, Canada

1 To whom correspondence should be addressed. Professor Emeritus, Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160. E-mail: jdoull@kumc.edu.

Received January 6, 2009; accepted January 12, 2009

The first 150 words of the full text of this article appear below.

Most toxicologists were pleased when the National Research Council appointed a committee in 2004 to review established methodologies and develop a long-range vision and strategy for toxicity testing in the future. This committee reviewed reports from the U.S. Environmental Protection Agency (EPA) and other sources and issued an interim report in 2006 entitled "Toxicity Testing for Assessment of Environmental Agents" (NCR, 2006Go). This report distinguished general toxicity tests from those designed to evaluate specific health effects and classified such tests as battery, tiered or tailored depending on the approach. It also reviewed the use of human data, alternative approaches and emerging technologies. Three chapters in this report included cogent committee observations and these sections plus the summarized information in boxes, tables and the appendix make this soft-cover report a valuable reference companion for the subsequent hard cover report. One of the many observations in this report is that toxicity . . . [Full Text of this Article]


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