ToxSci Advance Access originally published online on April 29, 2009
Toxicological Sciences 2009 110(1):244-245; doi:10.1093/toxsci/kfp082
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© The Author 2009. Published by Oxford University Press on behalf of the Society of Toxicology. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org
Nervous and Vestibular Toxicities of Acrylonitrile and Iminodipropionitrile

* Departament de Ciències Fisiològiques II
Departament d'Infermeria Fonamental i Medicoquirúrgica, Universitat de Barcelona, Hospitalet de Llobregat, Spain
1 To whom correspondence should be addressed at Departament de Ciències Fisiològiques II, Universitat de Barcelona, Feixa Llarga s/n, 08907 Hospitalet de Llobregat, Spain. Fax: +34-93-402-4268. E-mail: jllorens@ub.edu.
Received March 13, 2009; revision received March 20, 2009; accepted March 24, 2009
| The first 10% of the full text of this article appears below. |
A recent article by Khan et al. (2009)
in Toxicological Sciences deals with the putative mechanisms and target sites of acrylonitrile (ACN) and iminodipropionitrile (IDPN) in rats, and concludes that "the brain and vestibule appear to be major target sites of ACN and IDPN respectively." We think that the article raises several points that deserve comment.
The data reported by Khan et al. (2009)
for ACN include transient acute behavioral effects. Surprisingly, the authors do not explain how the effects recorded in
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