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© 1989 Oxford University Press

research-article

Disposition and Elimination of Three Polychlorinated Dibenzofurans in the Liver of the Rat1

MARTIN VAN DEN BERG1, JOOST DE JONGH2, PETRA ECKHART and FRANS W. M. VAN DEN WIELEN

Laboratory of Environmental and Toxicological Chemistry. University of Amsterdam Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands

Received June 6, 1988; accepted November 14, 1988

Disposition and Elimination of Three Polychlorinated Dibenzofurans in the Liver of the Rat. VAN DEN BERG, M., DE JONGH, J., ECKHART, P., AND VAN DER WIELEN, F. W. M. (1989). Fundam. Appl. Toxicol. 12, 738–747. The disposition and elimination of 1,2,3,6,7,8-HxCDF (HxCDF), 1,2,3,7,8-PnCDF (1-PnCDF), and 2,3,4,7,8-PnCDF (4-PnCDF) were studied in liver of female Sprague-Dawley rats after administration of a single oral dose of 3.5–6.3 µg/kg. The disposition of these PCDF congeners was structure and vehicle dependent. Administration in peanut oil caused the highest liver retention, compared with administration through the standard diet. Half-lives in liver for 1-PnCDF, 4-PnCDF, and HxCDF were 3.3, 108, and 73 days, respectively. 4-PnCDF showed very high liver retention: ≥70% of the dose in the first days after administration. To study kinetic interaction in the liver, mixtures of 1-PnCDF and 4-PnCDF (Experiment I) and of 4-PnCDF and HxCDF (Experiment II) were administered. The presence of 4-PnCDF in Experiment I did not significantly influence the half-life of I-PnCDF. In Experiment II the estimated half-life of 4-PnCDF was again 108 days, but for HxCDF an increased half-life was found, 156 days. It is concluded that PCDFs with a chlorine substituent(s) adjacent to the oxygen bridge (4- and 6-positions) are eliminated vcry slowly with 14 much greater than that of TCDD.


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