Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by PETERSEN, D. W.
Right arrow Articles by SMITH, L. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by PETERSEN, D. W.
Right arrow Articles by SMITH, L. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1989 Oxford University Press

research-article

Acute, Distribution, and Subchronic Toxicological Studies of Succinate Tartrates1,2,3

DEBORAH WISSINK PETERSEN*,4, JOHN F. POWERS{dagger}, MARILYN J. AARDEMA{dagger}, ROBERT A. LEBOEUF{dagger} and LAURENCE A. SMITH{ddagger}

*Human Safely Section, Ivorydale Technical Center, The Procter and Gamble Company Cincinnati, Ohio 45217 {dagger}Human and Environmental Safety Division, Miami Valley Laboratories, The Procter and Gamble Company Cincinnati, Ohio 45217 {ddagger}Products Chemistry and Analytical Section, Ivorydale Technical Center, The Procter and Gamble Company Cincinnati, Ohio 45217

Received September 2, 1988; accepted January 23, 1988

The estimated single-dose oral toxicity (50% lethality) of succinate tartrates (ST) was 2–3 g/kg in rats. ST produced minimal to moderate dermal irritation but no evidence of systemic toxicity in a standard acute percutaneous toxicity test in rabbits. ST was not an eye irritant in a standard rabbit low-volume eye irritation test ST was not genotoxic in a series of six genotoxicity tests. A 14-day oral gavage study in rats at a dose range of 0.05–1.0 g ST/kg/day produced only gastric irritation. The no-observed-effect level (NOEL) for gastric irritation was 0.1 g/kg for males and 0.05 g/kg for females. A 28-day percutaneous toxicity study in rabbits produced minimal to moderate dermal irritation and no adverse systemic effects at a high dose of 450 mg ST/kg/day. Single-dose absorption, distribution, and elimination (ADE) studies in male rats showed that 10–15% of an oral dose and 1–3% of a dermal dose were absorbed. Approximately 98% of the orally administered ST was eliminated as 14C in urine, feces, or expired CO2 after 72 hr. Approximately 80% of the dermally absorbed 14C dose was eliminated in urine, feces, or expired CO2 after 72 hr. In conclusion, no adverse effects were noted in acute toxicity, genotoxicity, or subchronic toxicity studies conducted with ST.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.