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© 1989 Oxford University Press

research-article

Effects of Glycerol on Lung and Liver Tumor Development

HANSPETER WITSCHI*,1, ALVIN M. MALKINSON{dagger}, CARL PERAINO{ddagger}, JOHN J. RUSSELL{ddagger} and E. F. STAFFELDT{ddagger}

*Biology Division, Oak Ridge National Laboratory OakRidge, Tennessee 37831 {dagger}Molecular and Environmental Toxicology Program, School of Pharmacy, University of Colorado Boulder, Colorado 80309 {ddagger}Biological, Environmental and Medical Research Division, Argonne National Laboratory Argonne, Illinois 60439

Received August 29, 1988; accepted January 9, 1989

Mice of several strains(A/J, SWR, MaMyJ, BALB/cByJ, 129J, and C57BL/6J) were treated with the carcinogens 3-methylcholanthrene, urethane, and 4-nitroquinoline 1 -oxide and then given 1 or 5% glycerol in the drinking water for up to 4 months. Effects of glycerol on lung tumor multiplicity and incidence were evaluated. The effects of glycerol were variable, and in the majority of experiments glycerol failed to enhance tumor development in mouse lung. Analysis of cell kinetics did not show a proliferative response of alveolar or bronchiolar cells to glycerol. In rats, glycerol did not enhance the appearance of putative preneoplastic liver foci, and in C3H mice it did not increase the incidence of spontaneously occurring liver tumors. It is concluded that glycerol does not increase number or incidence of lung tumors in the mouse strains used, whether the animals are pretreated with a carcinogen or not. Glycerol does not affect liver tumor development.


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