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© 1989 Oxford University Press

research-article

Current Problems Associated with Toxicity Evaluation of Medical Device Materials and Future Research Needs1

SHARON J. NORTHUP

Baxter Healthcare, Inc. P.O. Box 190, Round Lake, Illinois 60073

Received January 9, 1989; accepted January 17, 1989

The application of toxicology to the evaluation of medical device materials is reviewed. Strengths and weaknesses of systemic and local toxicity models are described. Developments needed to improve the methodology and predictability of assays for immunotoxicity and particulate toxicity are identified. Emerging methds are introduced for assessing adhesion, fibrosis, and blood compatibility.


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