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© 1989 Oxford University Press

research-article

Ethyl Chloride: 11-Day Continuous Exposure Inhalation Toxicity Study in B6C3F1 Mice

T. D. LANDRY, K. A. JOHNSON, J. E. PHILLIPS and S. K. WEISS

Mammalian and Environmental Toxicology Research Laboratory, Health and Environmental Sciences, The Dow Chemical Company 1803 Building, Midland, Michigan 48674

Received October 3, 1988; accepted May 5, 1989

Groups of seven B6C3FI mice per sex were exposed for 23 hr/day to 0, 250, 1250, or 5000 ppm ethyl chlonde (Eta) for 11 consecutive days to evaluate the potential toxicity of EtCl under near-continuous exposure conditions. On the day following the last exposure, a neurobehavioral observation battery was performed, samples were obtained for clinical chemistry and hematology, and necropsies were conducted. Histopathologic examination was subsequently performed. The only observed effects were increased relative liver weights and a slight increase in hepatocellular vacuolation (glycogen or fat) in 5000 ppm-exposed mice. Exposures to Eta were well tolerated despite the unusually long exposure periods.


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