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© 1989 Oxford University Press

research-article

Results and Evaluations of 48 Continuous Breeding Reproduction Studies Conducted in Mice

RICHARD E. MORRISSEY*,1, JAMES C. LAMB, IV*,2, RICHARD W. MORRIS{dagger}, ROBERT E. CHAPIN*, DUSHYANT K. GULATI{ddagger} and JERROLD J. HEINDEL*

*Developmental and Reproductive Toxicology Group, National Institute of Environmental Health Sciences, National Toxicology Program P.O. Box 12233, Research Triangle Park, North Carolina 27709 {dagger}Analytical Sciences Incorporated, 100 Capitola Drive, Suite 106, Durham, North Carolina 27713 {ddagger}Environmental Health Research and Testing Incorporated, 2514 Regency Road, Lexington, Kentucky 40503

Received February 13, 1989; accepted May 25, 1989

Results of 48 continuous breeding reproduction (RACB) studies are summarized and control data from these studies are used to determine the statistical sensitivity of each endpoint from different parts of these studies. Results of testing individual chemicals compared well with results of multigeneration studies reported in the literature. Continuous breeding studies were able to discriminate reproductive toxicants from nontoxicants, and provided valuable structure-activity information. When mice in continuous cohabitation produce multiple litters, the statistical sensitivity of fertility endpoints is quite high and is comparable to that associated with other sensitive indicators of reproductive function, such as testis weight and sperm parameter measures. The principal advantages of the RACB protocol in comparison to multigeneration studies are: (1) the increased sensitivity and statistical power, (2) the ability to monitor progression of toxicity and to detect subfertility, (3) use of a battery of endpoints including sperm measures, (4) the ability to determine the affected sex(es), and (5) slightly reduced testing time.


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