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© 1990 Oxford University Press

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Acute Inhalation Toxicity of T-2 Mycotoxin in the Rat and Guinea Pig

D. A. CREASIA*,1, J. D. THURMAN{dagger}, R. W. WANNEMACHER, JR.* and D. L. BUNNER*

*Pathophysiology Division, U.S. Army Medical Research Institute of Infectious Diseases Fort Detrick, Frederick, Maryland 21701-5011 {dagger}Pathology Division, U.S. Army Medical Research Institute of Infectious Diseases Fort Detrick, Frederick, Maryland 21701-5011

Received December 29, 1988; accepted July 5, 1989

Acute Inhalation Toxicity of T-2 Mycotoxin in the Rat and Guinea Pig. CREASIA, D. A., THURMAN, J. D., WANNEMACHER, R. W., JR., AND BUNNER, D. L. (1990). Fundam. Appl. Toxicol 14, 54–59. In this study, concentration-response parameters were determined for rats and guinea pigs systematically exposed to an aerosol of T-2 toxin. The LC50 for a 10-min exposure to T-2 toxin aerosol was 0.02 mg T-2/liter air for rats and 0.21 mg T-2/liter air for guinea pigs. Data from total T-2 deposition in rats and guinea pigs exposed to their respective LC50 aerosol concentration gave an LD50 of 0.05 mg T-2/kg body weight for the rat and 0.4 mg T-2/kg body weight for the guinea pig. These data show that inhaled T-2 toxin is approximately 20 times more toxic to the rat (0.05 mg T-2/kg body wt inhaled vs 1.0 mg T-2/kg body wt ip) and at least twice as toxic to the guinea pig (0.4 mg T-2/kg body wt inhaled vs 1-2 mg T-2/kg body wt ip) than ip administered T-2 toxin. Histopathologic examination of major organs in both the rat and guinea pig after respiratory exposure to T-2 toxin indicated that lesions were similar to those described after systemic administration of the toxin. Gross and microscopic alterations of respiratory tract tissue after T-2 aerosol exposure were minimal and could not account for the increase in toxicity.


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