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© 1990 Oxford University Press

other

Toxicity and Metabolism of Trimethylarsine in Mice and Hamsters

HIROSHI YAMAUCHI*,1, TOSHIKAZU KAISE{dagger}, KEIKO TAKAHASHI* and YUKIO YAMAMURA*

*Departmenl of Public Health, St. Marianna University School of Medicine 2-16-1, Sugao, Miyamae-ku, Kawasaki 213, Japan {dagger}Department of Food and Drug Science, Kanagawa Prefeclural Public Health Laboratory 52-2, Nakao-cho, Asahi-ku, Yokohama 241, Japan

Received September 8, 1989; accepted September 19, 1989

Toxicity and Metabolism of Trimethylaisinc in Mice and Hamsters. YAMAUCHI, H., KAISE, T., TAKAHASHI, K., AND YAMAMURA, Y. (1990). Fundam. Appl. Toxicol. 14, 399–407. Trimethylarsine (TM-As) proved to be an arsenic compound of low toxicity, with a po LD50 of 7870 mg/kg in mice. A single po dose of 10 mg/kg of TM-As caused no hemolysis, but a single po dose of 750 mg/kg induced mild, transient hemolysis in hamsters. TM-As was very rapidly eliminated into the urine, with a biological half-life of 3.7 hr. TM-As was oxidized In vivo to form trimethylarsine oxide (TMAO) and excreted as such into the urine. TM-As was never demethylated In vivo. A mechanism was demonstrated by which a part of TM-As was eliminated directly into the expired air. We drew a conclusion that TM-As is far less toxic than arsine, most probably due to its In vivo conversion to TMAO. c 1990 Society of Toxicology.


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