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© 1990 Oxford University Press

other

Effects of Environmental Temperature on Hypothermia and Neuroendocrine Changes Induced by Soman

R. P. MAIOCEL, D. R. KINNEY, N. D. RYKER and M. B. NICHOLS

Department of Pharmacology and Toxicology, Purdue University West Lafayette, Indiana 47906

Received May 30, 1989; accepted December 1, 1989

Effects of Environmental Temperature on Hypothermia and Neuroendocrine Changes Induced by Soman. MAICKEL, R. P., KJNNEY, D. R., RYKER, N. D., AND NICHOLS, M. B. (1990). Fundam. Appl. Toxicol 14, 696–705. The effects of environmental temperature on body temperature and neuroendocrine parameters were evaluated following a single acute dose (60 ngj kg) of soman. Plasma levels of corticosterone, glucose, and free fatty acids, as well as acetylcho-linesterase activity in plasma, erythrocytes, and brain were determined over a 96-hr time course in rats maintained at 23–25, 14–16, and 3–5°. Considerable inhibition of plasma and erythro-cyte acetylcholine hydrolysis activity was observed after administration of soman at all three environmental temperatures. The degree of hypothermia in all soman-treated rats in each environment tested was associated with the amount of brain acetylcholinesterase inhibition. In animals maintained at 23–25 and 14–16°C, changes in plasma corticosterone levels were influenced by central acetylcholine hydrolysis. Hyperglycemia was found only in rats with greater than 45% brain inhibition regardless of environmental temperature. However, the plasma concentration of glucose over the 96 hr test period varied in relation to the hydrolysis of acetylcholine in soman-treated rats. Recovery of plasma acetylcholinesterase was more rapid at lower environmental temperatures. A greater inhibition of central acetylcholinesterase was found in soman-treated rats exposed to 3–5°C. Soman may be more toxic at low environmental temperatures.


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