Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by BUCHER, J. R.
Right arrow Articles by RAGAN, H. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by BUCHER, J. R.
Right arrow Articles by RAGAN, H. A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1990 Oxford University Press

research-article

Inhalation Toxicity Studies of Cobalt Sulfate in F344/N Rats and B6C3F1 Mice

J. R. BUCHER, M. R. ELWELL, M. B. THOMPSON, B. J. CHOU*, R. RENNE* and H. A. RAGAN*

National Institute of Environmental Health Sciences, National Toxicology Program P.O. Box 12233, Research Triangle Park, North Carolina 27709 *Ballelie Memorial Institute, Pacific Northwest Laboratories P.O. Box 999, Richland, Washington 99352

Received December 31, 1989; accepted April 26, 1990

Inhalation Toxicity Studies of Cobalt Sulfate in F344/N Rats and B6C3F1 Mice. BUCHER, J. R., ELWELL, M. R., THOMPSON, M. B., CHOU, B. J., RENNE, R., AND RAGAN, H. A. (1990). Fundam. Appl. Toxicol. 15, 357–372. Groups of 10 F344/N rats and B6C3F1 mice of each sex were exposed to cobalt sulfate heptahydrate aerosols of 0, 0.3, 1.0, 3.0, 10, or 30 mg/m3, 6 hr per day, 5 days per week, for 13 weeks. All rats and female mice and all but 2/10 male mice exposed at the top concentration survived to the end of the studies. Polycythemia was observed in exposed rats but not in mice. Sperm motility was decreased in mice exposed at 3 mg/m3 (the lowest concentration evaluated) and at higher concentrations, and increased numbers of abnormal sperm and decreased testis and epididymal weights occurred in mice exposed to 30 mg/m3. Cobalt content in the urine of rats increased with increasing atmospheric cobalt exposure. Primary histopathologic effects were limited to the respiratory tract. Lesions in rats and mice included degeneration of the olfactory epithelium, squamous metaplasia of the respiratory epithelium, and inflammation in the nose; inflammation, necrosis, squamous metaplasia, ulcers (rats), and inflammatory polyps (rats) of the larynx; metaplasia of the trachea (mice); and fibro-sis, histiocytic infiltrates, bronchiolar epithelial regeneration, and epithelial hyperplasia in the alveoli of the lung. The most sensitive tissue was the larynx, with squamous metaplasia observed in rats and mice at the lowest exposure concentration of 0.3 mg/m3. Thus, a no-observed-adverse-effect level was not reached in these studies


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.