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© 1991 Oxford University Press

research-article

A Two-Generation Reproduction Study in Rats Receiving Diets Containing Hexamethylenediamine1

ROBERT D. SHORT*, FREDERICK R. JOHANNSEN* and JAMES L. SCHARDEIN{dagger}

*Monsanlo Company 800 North Lindbergh Boulevard, St. Louis, Missouri 63167 {dagger}IRDC 500 North Main Street, Mattawan, Michigan 49071

Received September 24, 1990; accepted November 20, 1990

A Two-Generation Reproduction Study in Rats Receiving Diets Containing Hexamethylenediamine. SHORT, R. D., JOHANNSEN, F. R., AND SCHARDEIN, J. L. (1991). Fundam. Appl. Toxicol. 16, 490–494. Rats received diets containing average daily doses of 0, 50, 150, and 500 mg/kg/ day of hexamethylenediamine over two generations. Although no treatment-related mortality was observed in any of the groups, the weight gain of adults and pups was slightly reduced in the high dose group. While the litter size was also slightly reduced at birth in the high dose group, there was no adverse effect on survival during lactation in any of the treated groups. Thus, the dietary administration of up to 150 mg/kg/day of hexamethylenediamine over two generations did not adversely affect reproduction or fertility in rats.


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