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© 1991 Oxford University Press

other

Early Effects of Lead on Bone Marrow Cell Responsiveness in Mice Challenged with Listeria monocytogenes1

MICHAEL KOWOLENKO2, LEIGH TRACY and DAVID LAWRENCE3

Albany Medical College, Department of Microbiology and Immunology Albany, New York 12208

Received September 7, 1990; accepted January 15, 1991

Early Effects of Lead on Bone Marrow Cell Responsiveness in Mice Challenged with Listeria monocytogenes. KOWOLENKO, M., TRACY, L., AND LAWRENCE, D. Fundam. Appl. Toxtcol. 17, 75–82. Listeria monocytogenes challenge of lead-treated mice results in increased mortality. Since macrophage development constitutes the initial phase of the immune response to L. monocytogenes, bone marrow and spleens from Pb-treated mice that were infected with L. monocytogenes were analyzed for their ability to form colonies when exposed to the macrophage growth factor CSF-1. Serum colony-stimulating activity also was evaluated. Data obtained indicate the Pb exposure results in decreased responsiveness of bone marrow and spleen cells to CSF-1 while colony-stimulating activity in serum rises. This lack of bone marrow-derived macrophage development may contribute to the increased mortality observed with L. monocytogenes challenged, Pb-treated mice.


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