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© 1991 Oxford University Press

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Suppression of Local Gut-Associated and Splenic Mitogen Responsiveness of Lymphoid Cells following Oral Exposure of B6C3F1 Mice to 7,12-Dimethylbenz[a]anthracene

Supprrsion of Local Gut-Associated and Splenic Mitogen Responsiveness of Lymphoid Cells following Oral Exposure of B6C3FI Mice to 7,12-Dimethylbenz[a]anthraane. DAVIS, D. P., GOMU, M. P., BARTON, S. L., MOKTANO, R. M., AND BURCHLEL, S. W. (1991). Fundam. Appl. Toxicol. 17,429–431. In these studies, the mitogen responsiveness of lymphocytes obtained from local gut-associated lymphoid tissues (GALT) and the spleen were evaluated following a 5-day exposure to 7,12-dimethylbcnz(a)anthracene (DMBA) at dcses of 50 or 150 mg/kg Phytohemaggluunin and lipopolysaccharide (LPS) nsponses were suppressed in all lymphod tissues studied. However. the LPS response in mesenteric lymph nodes and Peyer's Patches seemed to be the most sensitive indiator of immunotoxicity, indicating that B cells appear to be particularly sensitive to DMBA toxicity in-the GALT. These studies demonstrate that both splenic tissues and GALT are important targets of immunotoxicity following oral administration of DMBA. B a d upon these and past studies we conclude that the total administed dose of DMBA is a more important determinant of immunotoxicity than the length of exposure.


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