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© 1991 Oxford University Press

research-article

Comparative Hepatotoxicity of Two Polychlorotrifluoroethylenes (3.1 Oils) and Two Chlorotrifluoroethylene (CTFE) Oligomers in Male Fischer 344 Rats1

N. J. DELRASO*,2, C. S. GODIN{dagger}, C. E. JONES*, H. G. WALL{dagger}, D. R. MATTIE* and C. D. FLEMMING{dagger}

*Harry G. Armstrong Aerospace Medical Research Laboratory, Toxic Hazards Division wright-Patterson Air Force Base, Ohio 45433; {dagger}NSI Technology Services Corporation-Environmental Sciences 101 Woodman Drive, Suite 12, Dayton, Ohio 45431

Received April 30, 1990; accepted May 29, 1991

Comparative Hepatotoxicity of Two Polychlorotrifluoroethylenes (3.1 Oils) and Two Chlorotrifluoroethylene (CTFE) Oligomers in Male Fischer 344 Rats. DELRASO, N. J., GODIN, C. S., JONES, C. E., WALL, H. G., MATTIE, D. R., AND FLEMMING, C. D. (1991). Fundam. Appl. Toxicol. 17, 550–562. Polychlorotrifluoroethylene (3.1 oil) is a nonflammable hydraulic fluid composed of chlorotrifluoroethylene (CTFE) oligomers of different carbon chain lengths (C5 to C9), primarily six (trimer) and eight (tetramer) carbons. Four test groups of Fischer 344 rats(l6 rats/group) were orally gavaged daily over a 2-week period at doses of 1.25 g/kg with 3.1 oil containing a 55:45 ratio of trimer and tetramer(3.1 oil-C6:C3), 3.1 oil composed of 95% trimer (3.1 oil-C6), pure tetramer, and pure trimer. Four rats per treatment group were terminated after 1, 3, 7, and 14 doses. Rats dosed with either 3.1 oil-C6:C3 or pure tetramer demonstrated significant weight losses, increased liver weights, increased rates of liver fatty acid ß-oxidation, pronounced hepatomegaly and altered hepatocellular architecture, and elevated serum liver-associated enzymes. Rats dosed with either 3.1 oil-C6 or only pure trimer demonstrated significant increase in liver weight and moderate liver histopathologic changes. Compositional analyses of the ratio percentage of trimer to tetramer present in 3.1 oil-C6:C3 (55:45) were found to be altered when measured in the liver (32:68). Differential CTFE oligomer toxicity was indicated by effects on liver, body weight, and peroxisomal ß-oxidation and may allow for less toxic formulations of 3.1 oil to be generated by reducing or eliminating the tetramer component.


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