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© 1992 Oxford University Press

research-article

Chronic Toxicity Carcinogenicity Studies of Triethanolamine in B6C3F1 Mice

YOICHI KONISHI, AYUMI DENDA, KAZUHIKO UCHIDA, YOHKO EMI, HITOSHI URA, YOSHIHIKO YOKOSE, KAZUMI SHIRAIWA and MASAHIRO TSUTSUMI

Department of Oncological Pathology, Cancer Center, Nara Medical University 840 Shijo-cho, Kashihara, Nara 634, Japan

Received March 14, 1991; accepted June 25, 1991

The chronic toxicity and carcinogenic potential of triethanolamine was examined in B6C3F1 mice. Triethanolamine, dissolved in distilled water at levels of 0 (control), 1, and 2%, was given to groups of 50 males and 50 females ad libitum in drinking water for 82 weeks. Neoplasms developed in all groups, including the control group, but no dose-related increase of the incidence of any tumor was observed in treated groups of both sexes. There were no adverse effects as regards survival of the mice, organ weights, and specific incidence of neoplasms in the treated, compared to the control group. This chronic toxicity test provides no evidence of carcinogenic potential of triethanolamine in B6C3F1 mice.


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