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© 1992 Oxford University Press

research-article

Two-Generation Reproduction Study of Hydrotreated Shale Oil Vapors

CHARLES R. CLARK, PAUL W. FERGUSON*, MARK A. KATCHEN{dagger} and DOUGLAS K. CRAIG{ddagger}

Unocal Corporation, Los Angeles, California 90051 *Northeast Louisiana University Monroe, Louisiana 71201 {dagger}Environ Corporation Irvine, California 92714; {ddagger}Savannah River Laboratories Aiken, SC 29802

Received February 5, 1991; accepted August 22, 1991

Two generations of Sprague-Dawley rats were each exposed to vapors generated by countercurrent distillation (50°C) at 0, 0.5, 2.5, and 5.0 mg/liter, for 6 hr/day, 5 days/week, for 124–126 days prior to mating. After mating, exposure was continuous except for the last day of gestation through lactation for F0 dams, and the last day of gestation through Day 6 of lactation for F1 dams. F1 pups were not exposed during lactation; F2 pups were exposed via nursing only. Body weights were recorded weekly before mating; organ and body weights were recorded on Days 1, 13, and 30 of gestation and on Days 1, 4, and 21 of lactation. Histopathology, reproductive performance, and certain sperm parameters were evaluated. The test material significantly (p 0.05) depressed body weights of F0 males and brain and lung weights of F1 weanling males at 5.0 mg/liter. Testicular weights of F1 weanling males were depressed at the 0.5 and 5.0 mg/liter concentrations. While a dose-related decrease in sperm count and sperm ATP levels and an increase in ATP/sperm ratios were observed in F0 males at 2.5 and 5.0 mg/liter, there was no adverse effect on overall reproductive performance.


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