Skip Navigation

This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by MURPHY, S. J.
Right arrow Articles by ENGLISH, J. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by MURPHY, S. J.
Right arrow Articles by ENGLISH, J. C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 1992 Oxford University Press

research-article

A Study of Developmental Toxicity of Hydroquinone in the Rabbit1,2,3

S. J. MURPHY*,4, R. E. SCHROEDER{dagger}, A. M. BLACKER{ddagger}, W. J. KRASAVAGE§ and J. C. ENGLISH§

*Department 459B, Toxicology & Regulatory Compliance, Tile Good year Tire & Rubber Company, Akron Ohio 44305 {dagger}Reproduction/Teratology, Bio/dvnainics, Inc. East Alit/stone, New Jersey 088 75-2360 {ddagger}Rhone-Poulenc Inc, Research Triangle Park North Carolina 27709 §Health and Environment Labs, Eastman Kodak Company, Rochester New York 14652-3615

Received July 24, 1991; accepted January 31, 1992

To obtain information on potential developmental toxicity, hydroquinone (HQ) was administered to pregnant New Zealand White rabbits (18 mated per dose group) in aqueous solution (0, 25, 75, or 150 mg HQ/kg/day) by gavage on Gestation Days (GD) 6 to 18. Caesarean sections were performed on GD 30. Doses of 75 and 150 mg/kg/day adversely affected feed consumption and/or body weights of dams during the treatment period. At these doses, however, treatment-related effects were not evident from physical observations, liver and kidney weights, premature delivery incidence, and caesarean sectioning data. The NOEL for maternal toxicity was 25 mg/kg/day. In the 150 mg/ kg/day dose group, total incidences of external, visceral, and skeletal findings for fetuses did not differ statistically from controls. Slight, statistically insignificant, increases were found, however, in the incidences of ocular and minor skeletal malformations (microophthalmia, vertebral/rib defects, angulated hyoid arch) on both a per fetus and a per litter basis. Under the conditions of this study, HQ at 150 mg/kg/day produced minimal developmental alterations in the presence of maternal toxicity. The NOEL for developmental toxicity was 75 mg/kg/day.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.