© 1982 Oxford University Press
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1,1,3,3-Tetrachloroacetone: Teratogenicity Study in Mice and Rabbits1
Toxicology Research Laboratory, Health and Environmental Sciences Dow Chemical U.S.A., Midland, MI 48640; The National Institute of Environmental Health Sciences (NIEHS) Research Triangle Park, NC 27709
1,1,3,3-Tetrachloroacetone: Teratogenicity Study in Mice and Rabbits. John, J.A., Murray, F.J., Quast, J.F., Keeler, P.A., Schwetz, B.A. and Staples, R.E. (1982). Fundam. Appl. Toxicol. 2:220–225. The teratogenicity of tetrachlo-roacetone (TCA) was evaluated in CF-1 mice and New Zealand white rabbits. Mice were given 0, 5, 15 or 50 mg/kg/day of TCA by gavage on days 6 through 15 of gestation. Rabbits were given 0,1, 5, or 10 mg/kg/day on days 6 through 18 of gestation. The incidence of malformed fetuses was not significantly increased among mice given 5, 15 or 50 mg/kg/day of TCA. Sixteen fetuses in 3 litters in the 50 mg/kg/day group had cleft palate; they were from three dams which showed the most severe signs of toxicity, including depressed weight gain, decreased water consumption, and gastric ulceration. Dosage with 5 mg/kg/day, a level which was not toxic to the pregnant female, was not toxic to developing mouse fetuses. Fetal effects in rabbits were limited to a slight, but not statistically significant or dose related increase in the incidence of malformed fetuses. On the basis of these results, TCA does not appear to represent a unique hazard to the conceptus.